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Psychedelic Assisted Therapy
Info and Updates
Exploring Healing with Renewed Research
The psychedelic medicine renaissance is transforming mental health care and reshaping psychiatry. In the 1950s and 60s, psychedelics like psilocybin, LSD, and MDMA were studied for their potential to expand creativity, enhance mental health, and offer profound self-insight. However, by the 1970s, cultural and regulatory shifts halted most research. Today, psychedelics are making a comeback, with new studies suggesting they may help with depression, PTSD, anxiety, and addiction—ushering psychiatry into a promising new era.
In psychedelic-assisted therapy, these medicines act as catalysts in a safe, guided setting, helping individuals access deep emotions and insights that can be transformative with the support of a trained therapist. While some psychedelics show benefits on their own, the real breakthroughs often happen when combined with therapy, leading to powerful shifts in understanding, emotional resilience, and healing.
Equally essential is integration—bringing the insights from these experiences into daily life. Integration might include journaling, meditation, yoga, creative expression, or ongoing therapy, helping to reinforce these insights as a source of lasting positive change. The journey doesn’t end with the session; integration allows these experiences to foster ongoing growth and healing.
Be sure to check out some of our integration tools on our Offerings tab and on instagram @The_Kintsukuroi_Project. on your way out!
It's an exciting time in medicine. That said, it's important to stay legal and stay safe. Continue reading to learn a little bit more about psychedelic medicine and its history.
Introducing the Medicines
Click the images below to read a little more about each psychedelic medicine.
Psilocybin
Psilocybin, the active compound in “magic mushrooms,” is gaining attention for its potential in mental health treatment. Here’s an overview of its history, mechanisms, and therapeutic applications.
Mechanism of Action:
Psilocybin activates serotonin receptors, particularly 5-HT2A, enhancing neural connectivity. This “reset” effect may help disrupt patterns associated with depression, anxiety, and trauma, offering new perspectives.
Historical Context:
For millennia, psilocybin mushrooms have been integral to sacred practices, especially in indigenous rituals across the Americas. In the 1950s, R. Gordon Wasson and Mazatec healer María Sabina introduced psilocybin to Western audiences, leading to extensive research before its prohibition in the 1970s. Today, its therapeutic potential is being revisited.
Research Findings:
Studies indicate psilocybin’s potential in treating:
• Depression: Research from Johns Hopkins and Imperial College London demonstrates lasting relief after a few sessions.
• PTSD and Anxiety: Psilocybin may alleviate trauma-related symptoms and reduce end-of-life anxiety.
• Addiction: Preliminary studies suggest benefits in addressing substance dependence.
Therapeutic Experience:
Psilocybin-assisted therapy involves guided sessions with a therapist, facilitating exploration of deep emotions and insights. Many report a sense of “oneness” and a renewed life perspective, supporting healing and growth.
Future Outlook:
With the FDA granting “breakthrough therapy” status and states like Oregon developing legal frameworks, psilocybin is gaining traction. Ongoing research may solidify its role in mental health care.
Disclaimer: Psilocybin should only be used where legal and in therapeutic settings with trained professionals. Always approach psychedelics responsibly and respect local laws.
Mechanism of Action:
Psilocybin activates serotonin receptors, particularly 5-HT2A, enhancing neural connectivity. This “reset” effect may help disrupt patterns associated with depression, anxiety, and trauma, offering new perspectives.
Historical Context:
For millennia, psilocybin mushrooms have been integral to sacred practices, especially in indigenous rituals across the Americas. In the 1950s, R. Gordon Wasson and Mazatec healer María Sabina introduced psilocybin to Western audiences, leading to extensive research before its prohibition in the 1970s. Today, its therapeutic potential is being revisited.
Research Findings:
Studies indicate psilocybin’s potential in treating:
• Depression: Research from Johns Hopkins and Imperial College London demonstrates lasting relief after a few sessions.
• PTSD and Anxiety: Psilocybin may alleviate trauma-related symptoms and reduce end-of-life anxiety.
• Addiction: Preliminary studies suggest benefits in addressing substance dependence.
Therapeutic Experience:
Psilocybin-assisted therapy involves guided sessions with a therapist, facilitating exploration of deep emotions and insights. Many report a sense of “oneness” and a renewed life perspective, supporting healing and growth.
Future Outlook:
With the FDA granting “breakthrough therapy” status and states like Oregon developing legal frameworks, psilocybin is gaining traction. Ongoing research may solidify its role in mental health care.
Disclaimer: Psilocybin should only be used where legal and in therapeutic settings with trained professionals. Always approach psychedelics responsibly and respect local laws.
MDMA
MDMA: A Path to Healing Trauma
MDMA, or 3,4-Methylenedioxymethamphetamine, is emerging as a powerful tool in trauma therapy. Recognized by the FDA as a “breakthrough therapy,” MDMA-assisted therapy shows remarkable promise, especially for treatment-resistant PTSD. Here’s what you need to know about this transformative approach.
How MDMA Works:
MDMA increases serotonin, dopamine, and oxytocin—neurochemicals tied to mood, trust, and bonding. This helps people feel safe, open, and connected, making it easier to process traumatic memories without overwhelming fear.
MDMA’s Journey:
Initially used therapeutically in the 1970s and ‘80s, MDMA’s use was halted due to its recreational popularity. However, organizations like MAPS (Multidisciplinary Association for Psychedelic Studies) have reignited research, pushing for its approval as a therapeutic tool for PTSD.
Research & Results:
Studies show MDMA-assisted therapy’s potential for lasting relief from PTSD and related conditions:
• PTSD Relief: MAPS’ Phase 3 trials show over 60% of participants experience lasting symptom reduction after only a few sessions.
• Anxiety & Depression: MDMA’s ability to foster emotional openness holds promise for treating social anxiety and depression.
The Therapeutic Experience:
MDMA-assisted therapy occurs in a safe, therapeutic setting with trained therapists. MDMA allows individuals to access emotions and memories they may otherwise avoid, supporting deep healing. Participants often describe feeling safe, clear-minded, and compassionate toward themselves.
The Path Forward:
With MAPS leading the way, MDMA-assisted therapy is expected to gain FDA approval in the coming years. Australia has also recently approved MDMA therapy for PTSD at a federal level, signaling a new era for MDMA in trauma recovery.
Disclaimer: MDMA should only be used legally and under professional supervision. Misuse of this substance has been linked to drug-facilitated assault.
MDMA, or 3,4-Methylenedioxymethamphetamine, is emerging as a powerful tool in trauma therapy. Recognized by the FDA as a “breakthrough therapy,” MDMA-assisted therapy shows remarkable promise, especially for treatment-resistant PTSD. Here’s what you need to know about this transformative approach.
How MDMA Works:
MDMA increases serotonin, dopamine, and oxytocin—neurochemicals tied to mood, trust, and bonding. This helps people feel safe, open, and connected, making it easier to process traumatic memories without overwhelming fear.
MDMA’s Journey:
Initially used therapeutically in the 1970s and ‘80s, MDMA’s use was halted due to its recreational popularity. However, organizations like MAPS (Multidisciplinary Association for Psychedelic Studies) have reignited research, pushing for its approval as a therapeutic tool for PTSD.
Research & Results:
Studies show MDMA-assisted therapy’s potential for lasting relief from PTSD and related conditions:
• PTSD Relief: MAPS’ Phase 3 trials show over 60% of participants experience lasting symptom reduction after only a few sessions.
• Anxiety & Depression: MDMA’s ability to foster emotional openness holds promise for treating social anxiety and depression.
The Therapeutic Experience:
MDMA-assisted therapy occurs in a safe, therapeutic setting with trained therapists. MDMA allows individuals to access emotions and memories they may otherwise avoid, supporting deep healing. Participants often describe feeling safe, clear-minded, and compassionate toward themselves.
The Path Forward:
With MAPS leading the way, MDMA-assisted therapy is expected to gain FDA approval in the coming years. Australia has also recently approved MDMA therapy for PTSD at a federal level, signaling a new era for MDMA in trauma recovery.
Disclaimer: MDMA should only be used legally and under professional supervision. Misuse of this substance has been linked to drug-facilitated assault.
LSD
LSD: Exploring the Mind and Healing Potential
Lysergic Acid Diethylamide (LSD) is a well-known psychedelic with a rich history in both cultural and therapeutic contexts. First synthesized in 1938 by Swiss chemist Albert Hofmann, LSD gained popularity in the 1950s and ’60s for its mind-expanding effects and was extensively researched for mental health treatment. Today, it is re-emerging as a promising tool in therapy.
How LSD Works:
LSD primarily affects serotonin receptors, especially 5-HT2A, influencing mood, perception, and cognition. This interaction can help individuals explore thoughts and emotions in new ways, leading to breakthroughs in therapy.
LSD’s Journey:
After its discovery, LSD was widely researched in psychiatry until regulatory restrictions in the 1970s halted its study. Today, research is re-emerging, focusing on its therapeutic potential for conditions like anxiety, depression, and addiction.
Research & Results:
Studies suggest LSD-assisted therapy could help with:
• Anxiety & Depression: LSD can foster new perspectives and connections, supporting mood improvement.
• End-of-Life Anxiety: It shows promise in easing distress for terminally ill patients.
• Addiction: Early research suggests LSD may help break addiction by promoting insights and behavior changes.
The Therapeutic Experience:
LSD-assisted therapy is conducted in a safe, supportive environment with guidance from trained therapists. Sessions may involve vivid visuals, emotional exploration, and a sense of interconnectedness, offering “mind-expanding” experiences that help participants gain new life perspectives.
Looking Forward:
As research progresses, LSD-assisted therapy could become a valuable tool for treating anxiety, depression, and addiction. With renewed interest and careful study, LSD is poised to play a role in the future of psychedelic healing.
Disclaimer: LSD use should only be conducted legally and with trained professionals. Always respect legal guidelines and approach psychedelics responsibly.
Lysergic Acid Diethylamide (LSD) is a well-known psychedelic with a rich history in both cultural and therapeutic contexts. First synthesized in 1938 by Swiss chemist Albert Hofmann, LSD gained popularity in the 1950s and ’60s for its mind-expanding effects and was extensively researched for mental health treatment. Today, it is re-emerging as a promising tool in therapy.
How LSD Works:
LSD primarily affects serotonin receptors, especially 5-HT2A, influencing mood, perception, and cognition. This interaction can help individuals explore thoughts and emotions in new ways, leading to breakthroughs in therapy.
LSD’s Journey:
After its discovery, LSD was widely researched in psychiatry until regulatory restrictions in the 1970s halted its study. Today, research is re-emerging, focusing on its therapeutic potential for conditions like anxiety, depression, and addiction.
Research & Results:
Studies suggest LSD-assisted therapy could help with:
• Anxiety & Depression: LSD can foster new perspectives and connections, supporting mood improvement.
• End-of-Life Anxiety: It shows promise in easing distress for terminally ill patients.
• Addiction: Early research suggests LSD may help break addiction by promoting insights and behavior changes.
The Therapeutic Experience:
LSD-assisted therapy is conducted in a safe, supportive environment with guidance from trained therapists. Sessions may involve vivid visuals, emotional exploration, and a sense of interconnectedness, offering “mind-expanding” experiences that help participants gain new life perspectives.
Looking Forward:
As research progresses, LSD-assisted therapy could become a valuable tool for treating anxiety, depression, and addiction. With renewed interest and careful study, LSD is poised to play a role in the future of psychedelic healing.
Disclaimer: LSD use should only be conducted legally and with trained professionals. Always respect legal guidelines and approach psychedelics responsibly.
Ketamine
Ketamine: A New Hope for Mental Health
Originally developed as an anesthetic, ketamine has emerged as a promising treatment for mental health conditions, particularly depression and PTSD. Here’s an overview of its therapeutic benefits and role in mental health care.
How Ketamine Works:
Ketamine interacts with NMDA receptors, enhancing glutamate activity and promoting neural connectivity. This mechanism can “reset” mood and cognition, often providing rapid relief from depression within hours.
From Anesthetic to Antidepressant:
Discovered in the 1960s, ketamine’s potential for mental health treatment wasn’t fully explored until recent decades. Researchers found that low-dose ketamine infusions could relieve depression, even in individuals resistant to other treatments. Today, it is recognized for its support in mental health care.
What Research Shows:
Studies highlight ketamine’s potential for:
• Treatment-Resistant Depression: Many patients experience rapid relief, making it effective when other treatments have failed.
• PTSD & Anxiety: Ketamine can help reduce symptoms of PTSD and anxiety.
• Suicidal Ideation: Its fast-acting effects support those experiencing acute suicidal thoughts.
The Therapeutic Experience:
Ketamine-assisted therapy involves low-dose infusions in a clinical setting, often with guidance from trained therapists. Many describe the experience as calming, with mild visual effects and a sense of mental clarity. Integration support helps patients process insights and achieve lasting benefits.
The Future:
Ketamine clinics are now widely available, offering new hope for those seeking relief from severe depression, PTSD, and anxiety. As research expands, ketamine’s role in mental health care continues to grow.
Disclaimer: Ketamine should only be used under professional supervision in approved clinical settings. Always approach treatments responsibly and in line with local regulations.
Originally developed as an anesthetic, ketamine has emerged as a promising treatment for mental health conditions, particularly depression and PTSD. Here’s an overview of its therapeutic benefits and role in mental health care.
How Ketamine Works:
Ketamine interacts with NMDA receptors, enhancing glutamate activity and promoting neural connectivity. This mechanism can “reset” mood and cognition, often providing rapid relief from depression within hours.
From Anesthetic to Antidepressant:
Discovered in the 1960s, ketamine’s potential for mental health treatment wasn’t fully explored until recent decades. Researchers found that low-dose ketamine infusions could relieve depression, even in individuals resistant to other treatments. Today, it is recognized for its support in mental health care.
What Research Shows:
Studies highlight ketamine’s potential for:
• Treatment-Resistant Depression: Many patients experience rapid relief, making it effective when other treatments have failed.
• PTSD & Anxiety: Ketamine can help reduce symptoms of PTSD and anxiety.
• Suicidal Ideation: Its fast-acting effects support those experiencing acute suicidal thoughts.
The Therapeutic Experience:
Ketamine-assisted therapy involves low-dose infusions in a clinical setting, often with guidance from trained therapists. Many describe the experience as calming, with mild visual effects and a sense of mental clarity. Integration support helps patients process insights and achieve lasting benefits.
The Future:
Ketamine clinics are now widely available, offering new hope for those seeking relief from severe depression, PTSD, and anxiety. As research expands, ketamine’s role in mental health care continues to grow.
Disclaimer: Ketamine should only be used under professional supervision in approved clinical settings. Always approach treatments responsibly and in line with local regulations.
DMT
DMT: The Spirit Molecule for Transformation
Dimethyltryptamine (DMT) is a potent psychedelic known for inducing brief yet profound experiences. Historically integral to indigenous ceremonies, DMT is now under scientific investigation for its therapeutic potential in mental health.
Mechanism of Action:
DMT primarily affects serotonin receptors, notably 5-HT2A, leading to significant changes in perception and consciousness. This interaction can unlock subconscious emotions, often sparking transformative insights and a profound sense of connection.
Ceremonial Roots:
For centuries, DMT has been used in Amazonian cultures, primarily as ayahuasca, a ceremonial brew. Indigenous shamans utilize ayahuasca for spiritual guidance and healing, viewing it as a sacred tool for connecting with nature and the spirit world. Today, DMT is recognized worldwide for its potential in healing and growth.
Research Insights:
While research is still emerging, DMT shows promise for:
• PTSD & Trauma: DMT’s visionary experience may help process trauma by accessing repressed emotions.
• End-of-Life Anxiety: Its capacity for mystical experiences can reduce fear around death.
• Depression: DMT may create lasting shifts in mood and perspective, helping break negative patterns.
The DMT Experience:
DMT experiences are often described as “otherworldly,” featuring vivid visuals and a sense of leaving the body. Many report encounters with “spiritual” entities or realms, returning with insights, peace, and a feeling of interconnectedness. These journeys are typically brief, lasting only 10–30 minutes.
Future Directions:
With growing interest in DMT’s potential, researchers are exploring its role in mental health and personal growth. This compound bridges ancient traditions with modern science, offering a unique path to healing.
Disclaimer: DMT should only be used where legal and in therapeutic settings with experienced professionals. Always approach psychedelics responsibly and in line with local laws.
Dimethyltryptamine (DMT) is a potent psychedelic known for inducing brief yet profound experiences. Historically integral to indigenous ceremonies, DMT is now under scientific investigation for its therapeutic potential in mental health.
Mechanism of Action:
DMT primarily affects serotonin receptors, notably 5-HT2A, leading to significant changes in perception and consciousness. This interaction can unlock subconscious emotions, often sparking transformative insights and a profound sense of connection.
Ceremonial Roots:
For centuries, DMT has been used in Amazonian cultures, primarily as ayahuasca, a ceremonial brew. Indigenous shamans utilize ayahuasca for spiritual guidance and healing, viewing it as a sacred tool for connecting with nature and the spirit world. Today, DMT is recognized worldwide for its potential in healing and growth.
Research Insights:
While research is still emerging, DMT shows promise for:
• PTSD & Trauma: DMT’s visionary experience may help process trauma by accessing repressed emotions.
• End-of-Life Anxiety: Its capacity for mystical experiences can reduce fear around death.
• Depression: DMT may create lasting shifts in mood and perspective, helping break negative patterns.
The DMT Experience:
DMT experiences are often described as “otherworldly,” featuring vivid visuals and a sense of leaving the body. Many report encounters with “spiritual” entities or realms, returning with insights, peace, and a feeling of interconnectedness. These journeys are typically brief, lasting only 10–30 minutes.
Future Directions:
With growing interest in DMT’s potential, researchers are exploring its role in mental health and personal growth. This compound bridges ancient traditions with modern science, offering a unique path to healing.
Disclaimer: DMT should only be used where legal and in therapeutic settings with experienced professionals. Always approach psychedelics responsibly and in line with local laws.
Ayahuasca
Ayahuasca: A Journey of Deep Healing
Ayahuasca, a sacred Amazonian plant medicine, is known for its profound, introspective experiences that foster healing and self-discovery. Used for centuries by indigenous communities for spiritual and medicinal purposes, ayahuasca is now recognized globally for its therapeutic potential.
How Ayahuasca Works:
Ayahuasca is made from the ayahuasca vine (Banisteriopsis caapi) and a DMT-containing plant like chacruna (Psychotria viridis). Together, they activate serotonin receptors, leading to powerful visionary experiences and emotional release, which may help people process trauma, depression, and anxiety.
Indigenous Roots:
For generations, Amazonian shamans have used ayahuasca in ceremonies for healing, spiritual guidance, and connecting with the natural world. These ceremonies are deeply respectful and involve prayer, music, and guidance from experienced healers.
Therapeutic Potential:
Research on ayahuasca shows promise for:
• PTSD & Trauma: Ayahuasca may help individuals release deeply held emotions.
• Depression & Anxiety: Studies suggest lasting mood shifts.
• Addiction: Ayahuasca supports recovery by revealing underlying issues.
The Ayahuasca Experience:
Ayahuasca ceremonies are intense, with vivid visuals, emotional purging, and a sense of profound connectedness. Many experience a “life review,” gaining insights, forgiveness, and renewed purpose. This journey typically lasts 4–6 hours.
The Future:
With rising interest, more research is underway to understand ayahuasca’s benefits. This ancient medicine continues to bridge traditional wisdom with modern mental health approaches.
Disclaimer: Ayahuasca should only be used legally and in ceremonial settings with experienced facilitators. Approach this medicine with respect, intention, and awareness of local laws.
Ayahuasca, a sacred Amazonian plant medicine, is known for its profound, introspective experiences that foster healing and self-discovery. Used for centuries by indigenous communities for spiritual and medicinal purposes, ayahuasca is now recognized globally for its therapeutic potential.
How Ayahuasca Works:
Ayahuasca is made from the ayahuasca vine (Banisteriopsis caapi) and a DMT-containing plant like chacruna (Psychotria viridis). Together, they activate serotonin receptors, leading to powerful visionary experiences and emotional release, which may help people process trauma, depression, and anxiety.
Indigenous Roots:
For generations, Amazonian shamans have used ayahuasca in ceremonies for healing, spiritual guidance, and connecting with the natural world. These ceremonies are deeply respectful and involve prayer, music, and guidance from experienced healers.
Therapeutic Potential:
Research on ayahuasca shows promise for:
• PTSD & Trauma: Ayahuasca may help individuals release deeply held emotions.
• Depression & Anxiety: Studies suggest lasting mood shifts.
• Addiction: Ayahuasca supports recovery by revealing underlying issues.
The Ayahuasca Experience:
Ayahuasca ceremonies are intense, with vivid visuals, emotional purging, and a sense of profound connectedness. Many experience a “life review,” gaining insights, forgiveness, and renewed purpose. This journey typically lasts 4–6 hours.
The Future:
With rising interest, more research is underway to understand ayahuasca’s benefits. This ancient medicine continues to bridge traditional wisdom with modern mental health approaches.
Disclaimer: Ayahuasca should only be used legally and in ceremonial settings with experienced facilitators. Approach this medicine with respect, intention, and awareness of local laws.
Mescaline
Mescaline: Healing Through Peyote & San Pedro
Mescaline, a natural psychedelic found in cacti such as peyote (Lophophora williamsii) and San Pedro (Echinopsis pachanoi), has been used for centuries in indigenous ceremonies. Known for its heart-opening, reflective effects, mescaline is now recognized for its potential in mental health and personal growth.
How Mescaline Works:
Mescaline interacts with serotonin receptors, especially 5-HT2A, creating shifts in perception, mood, and consciousness. This interaction can lead to feelings of connection, introspection, and emotional release, offering new perspectives and insights.
Cultural Roots:
For generations, Native American and Andean cultures have used peyote and San Pedro in sacred ceremonies for healing and spiritual guidance. These ceremonies, often led by experienced guides, incorporate prayer, song, and ritual to create a meaningful journey.
Therapeutic Potential:
Emerging research suggests mescaline may help with:
• Depression & Anxiety: Assists in exploring core emotional issues.
• Addiction: Used in indigenous settings to support recovery.
• Spiritual Connection: Many report a deep sense of unity and personal insight.
The Mescaline Experience:
Mescaline journeys are known for their gentle, introspective nature, often featuring colorful visuals, a sense of interconnectedness, and feelings of gratitude. The experience typically lasts 6–10 hours, offering a space for emotional and spiritual exploration.
The Path Forward:
With renewed interest, mescaline is being studied for therapeutic applications, bridging traditional wisdom with modern mental health approaches.
Disclaimer: Mescaline use should only be conducted legally and with experienced guidance, especially in ceremonial settings. Approach responsibly, respecting local laws and practices.
Mescaline, a natural psychedelic found in cacti such as peyote (Lophophora williamsii) and San Pedro (Echinopsis pachanoi), has been used for centuries in indigenous ceremonies. Known for its heart-opening, reflective effects, mescaline is now recognized for its potential in mental health and personal growth.
How Mescaline Works:
Mescaline interacts with serotonin receptors, especially 5-HT2A, creating shifts in perception, mood, and consciousness. This interaction can lead to feelings of connection, introspection, and emotional release, offering new perspectives and insights.
Cultural Roots:
For generations, Native American and Andean cultures have used peyote and San Pedro in sacred ceremonies for healing and spiritual guidance. These ceremonies, often led by experienced guides, incorporate prayer, song, and ritual to create a meaningful journey.
Therapeutic Potential:
Emerging research suggests mescaline may help with:
• Depression & Anxiety: Assists in exploring core emotional issues.
• Addiction: Used in indigenous settings to support recovery.
• Spiritual Connection: Many report a deep sense of unity and personal insight.
The Mescaline Experience:
Mescaline journeys are known for their gentle, introspective nature, often featuring colorful visuals, a sense of interconnectedness, and feelings of gratitude. The experience typically lasts 6–10 hours, offering a space for emotional and spiritual exploration.
The Path Forward:
With renewed interest, mescaline is being studied for therapeutic applications, bridging traditional wisdom with modern mental health approaches.
Disclaimer: Mescaline use should only be conducted legally and with experienced guidance, especially in ceremonial settings. Approach responsibly, respecting local laws and practices.
Iboga/Ibogaine
Iboga/Ibogaine: A Powerful Path to Healing
Iboga, a root from Central Africa, and its derivative, ibogaine, are potent substances traditionally used for healing and self-discovery. Known for their transformative potential, ibogaine is gaining recognition for its effectiveness in addiction treatment and trauma recovery.
How Ibogaine Works:
Ibogaine interacts with multiple neurotransmitter systems, including serotonin and dopamine, helping to reset the brain’s reward pathways. This process may reduce withdrawal symptoms and cravings, making it especially promising for addiction treatment.
Cultural Roots:
Iboga has been used for centuries in Bwiti spiritual ceremonies in Gabon and other Central African regions. These ceremonies are profound experiences guided by trained practitioners, focusing on spiritual growth, ancestral connection, and deep healing.
Therapeutic Potential:
Emerging research suggests ibogaine may help with:
• Addiction: Known for interrupting addiction cycles, particularly with opioids and stimulants.
• PTSD & Trauma: Ibogaine’s introspective effects help individuals confront and process past trauma.
• Spiritual Insight: Many report deep insights, helping them find meaning and purpose.
The Ibogaine Experience:
Ibogaine journeys are intense, introspective, and often physically demanding, lasting up to 24 hours. Participants may experience vivid visions, personal reflections, and a sense of life review, offering a deep, transformative healing experience.
The Path Forward:
As research expands, ibogaine is being explored for its therapeutic potential, bridging indigenous wisdom with modern addiction and trauma treatment.
Disclaimer: Ibogaine should only be used where legal and under the supervision of experienced professionals. Approach with respect, intention, and awareness of local laws and cultural practices.
Iboga, a root from Central Africa, and its derivative, ibogaine, are potent substances traditionally used for healing and self-discovery. Known for their transformative potential, ibogaine is gaining recognition for its effectiveness in addiction treatment and trauma recovery.
How Ibogaine Works:
Ibogaine interacts with multiple neurotransmitter systems, including serotonin and dopamine, helping to reset the brain’s reward pathways. This process may reduce withdrawal symptoms and cravings, making it especially promising for addiction treatment.
Cultural Roots:
Iboga has been used for centuries in Bwiti spiritual ceremonies in Gabon and other Central African regions. These ceremonies are profound experiences guided by trained practitioners, focusing on spiritual growth, ancestral connection, and deep healing.
Therapeutic Potential:
Emerging research suggests ibogaine may help with:
• Addiction: Known for interrupting addiction cycles, particularly with opioids and stimulants.
• PTSD & Trauma: Ibogaine’s introspective effects help individuals confront and process past trauma.
• Spiritual Insight: Many report deep insights, helping them find meaning and purpose.
The Ibogaine Experience:
Ibogaine journeys are intense, introspective, and often physically demanding, lasting up to 24 hours. Participants may experience vivid visions, personal reflections, and a sense of life review, offering a deep, transformative healing experience.
The Path Forward:
As research expands, ibogaine is being explored for its therapeutic potential, bridging indigenous wisdom with modern addiction and trauma treatment.
Disclaimer: Ibogaine should only be used where legal and under the supervision of experienced professionals. Approach with respect, intention, and awareness of local laws and cultural practices.
Bufo (5-MeO-DMT)
Bufo (5-MeO-DMT): A Journey to the Mystical
5-MeO-DMT, often referred to as “Bufo” due to its presence in the secretion of the Bufo alvarius toad, is among the most potent psychedelics known. Renowned for inducing profound, mystical experiences, Bufo is gaining attention for its potential in mental health and spiritual exploration.
How 5-MeO-DMT Works:
5-MeO-DMT primarily acts on serotonin receptors, rapidly altering consciousness and perception. This intense experience can dissolve the sense of self, creating a feeling of unity and oneness that many describe as life-changing.
Traditional Use:
While synthetic 5-MeO-DMT is available, the natural form is derived from the Bufo alvarius toad, found in the Sonoran Desert. Indigenous groups have used Bufo ceremonially, emphasizing respect and reverence for its powerful effects.
Therapeutic Potential:
Research on 5-MeO-DMT is still emerging, but early insights suggest it may help with:
• Depression & Anxiety: The experience of interconnectedness and peace can lead to shifts in mood and outlook.
• PTSD & Trauma: Some report deep emotional release and healing.
• Spiritual Growth: Many experience profound insights and a renewed sense of purpose.
The Bufo Experience:
The Bufo journey is intense but brief, often lasting 15–30 minutes. Participants describe powerful visuals, sensations of merging with the universe, and a feeling of rebirth or clarity. This transformative experience is often guided by experienced practitioners to ensure safety and integration.
The Path Forward:
As interest in 5-MeO-DMT grows, more research is focusing on its therapeutic potential and safe, respectful use. This unique medicine offers a bridge between traditional practices and modern mental health approaches.
Disclaimer: Bufo (5-MeO-DMT) should only be used legally and with experienced guidance in safe settings. Approach with respect, responsibility, and awareness of local laws.
5-MeO-DMT, often referred to as “Bufo” due to its presence in the secretion of the Bufo alvarius toad, is among the most potent psychedelics known. Renowned for inducing profound, mystical experiences, Bufo is gaining attention for its potential in mental health and spiritual exploration.
How 5-MeO-DMT Works:
5-MeO-DMT primarily acts on serotonin receptors, rapidly altering consciousness and perception. This intense experience can dissolve the sense of self, creating a feeling of unity and oneness that many describe as life-changing.
Traditional Use:
While synthetic 5-MeO-DMT is available, the natural form is derived from the Bufo alvarius toad, found in the Sonoran Desert. Indigenous groups have used Bufo ceremonially, emphasizing respect and reverence for its powerful effects.
Therapeutic Potential:
Research on 5-MeO-DMT is still emerging, but early insights suggest it may help with:
• Depression & Anxiety: The experience of interconnectedness and peace can lead to shifts in mood and outlook.
• PTSD & Trauma: Some report deep emotional release and healing.
• Spiritual Growth: Many experience profound insights and a renewed sense of purpose.
The Bufo Experience:
The Bufo journey is intense but brief, often lasting 15–30 minutes. Participants describe powerful visuals, sensations of merging with the universe, and a feeling of rebirth or clarity. This transformative experience is often guided by experienced practitioners to ensure safety and integration.
The Path Forward:
As interest in 5-MeO-DMT grows, more research is focusing on its therapeutic potential and safe, respectful use. This unique medicine offers a bridge between traditional practices and modern mental health approaches.
Disclaimer: Bufo (5-MeO-DMT) should only be used legally and with experienced guidance in safe settings. Approach with respect, responsibility, and awareness of local laws.
Salvia
Salvia Divinorum: A Unique Path to Insight
Salvia divinorum, a potent plant native to Mexico, is renowned for its intense, short-lived psychedelic effects. Traditionally used by Mazatec shamans for healing and divination, salvia offers experiences distinct from other psychedelics, providing opportunities for deep introspection and personal insight.
How Salvia Works:
The active compound in salvia, salvinorin A, primarily affects kappa opioid receptors, leading to dramatic shifts in perception. This unique mechanism results in immersive experiences that can challenge one’s sense of reality.
Traditional Roots:
In Oaxaca, Mexico, Mazatec shamans have long utilized salvia in healing rituals. They typically chew the leaves or prepare a tea, guiding participants through visions to gain insight and spiritual connection.
Therapeutic Potential:
While research is limited, potential benefits include:
• Depression: Preliminary studies suggest salvia may help individuals explore unresolved emotions.
• Addiction: Its perceptual effects may support insights into breaking addictive patterns.
• Personal Insight: Many users report profound introspective experiences.
The Salvia Experience:
Salvia journeys are brief but intense, often lasting 5–10 minutes. Users commonly report sensations of entering other realms, experiencing unusual visuals, and feeling a separation from their usual sense of self. It’s best experienced in a calm, controlled setting with support for integration.
The Path Forward:
With growing interest, further research may uncover additional therapeutic uses for salvia. This unique plant continues to bridge traditional Mazatec wisdom with modern exploration.
Disclaimer: Salvia should be used legally and with caution due to its intense effects. Approach responsibly in safe settings, respecting local laws.
Salvia divinorum, a potent plant native to Mexico, is renowned for its intense, short-lived psychedelic effects. Traditionally used by Mazatec shamans for healing and divination, salvia offers experiences distinct from other psychedelics, providing opportunities for deep introspection and personal insight.
How Salvia Works:
The active compound in salvia, salvinorin A, primarily affects kappa opioid receptors, leading to dramatic shifts in perception. This unique mechanism results in immersive experiences that can challenge one’s sense of reality.
Traditional Roots:
In Oaxaca, Mexico, Mazatec shamans have long utilized salvia in healing rituals. They typically chew the leaves or prepare a tea, guiding participants through visions to gain insight and spiritual connection.
Therapeutic Potential:
While research is limited, potential benefits include:
• Depression: Preliminary studies suggest salvia may help individuals explore unresolved emotions.
• Addiction: Its perceptual effects may support insights into breaking addictive patterns.
• Personal Insight: Many users report profound introspective experiences.
The Salvia Experience:
Salvia journeys are brief but intense, often lasting 5–10 minutes. Users commonly report sensations of entering other realms, experiencing unusual visuals, and feeling a separation from their usual sense of self. It’s best experienced in a calm, controlled setting with support for integration.
The Path Forward:
With growing interest, further research may uncover additional therapeutic uses for salvia. This unique plant continues to bridge traditional Mazatec wisdom with modern exploration.
Disclaimer: Salvia should be used legally and with caution due to its intense effects. Approach responsibly in safe settings, respecting local laws.
Sananga
Sananga: Amazonian Eye Drops for Clarity and Healing
Sananga is a traditional Amazonian eye drop made from the roots and bark of the Tabernaemontana shrub. Indigenous tribes, such as the Kaxinawá, use Sananga in hunting and spiritual rituals to improve focus, clear energy blockages, and support both physical and spiritual vision.
How Sananga Works:
When applied directly to the eyes, Sananga induces a burning sensation lasting a few minutes. This effect is believed to stimulate the mind-body connection, purify energy fields, and open pathways to deeper perception and insight.
Potential Benefits:
Sananga is used for both physical and energetic healing, including:
• Improved Vision: It is believed to sharpen eyesight and heighten awareness.
• Energy Cleansing: Sananga is used to clear negative energies and balance the body.
• Spiritual Awareness: Many report an enhanced sense of clarity and connection.
The Sananga Experience:
The application of Sananga is known for its brief yet intense sensation, lasting about 5–10 minutes. After the initial burning subsides, users often experience a sense of clarity, calm, and focus, feeling more connected and grounded.
The Path Forward:
As interest grows, Sananga continues to bridge Amazonian wisdom with modern spiritual practices, offering a unique tool for those seeking clarity and energetic balance.
Disclaimer: Sananga should be used under the guidance of an experienced practitioner and only where legally permitted. Approach with respect, intention, and awareness of local laws.
Sananga is a traditional Amazonian eye drop made from the roots and bark of the Tabernaemontana shrub. Indigenous tribes, such as the Kaxinawá, use Sananga in hunting and spiritual rituals to improve focus, clear energy blockages, and support both physical and spiritual vision.
How Sananga Works:
When applied directly to the eyes, Sananga induces a burning sensation lasting a few minutes. This effect is believed to stimulate the mind-body connection, purify energy fields, and open pathways to deeper perception and insight.
Potential Benefits:
Sananga is used for both physical and energetic healing, including:
• Improved Vision: It is believed to sharpen eyesight and heighten awareness.
• Energy Cleansing: Sananga is used to clear negative energies and balance the body.
• Spiritual Awareness: Many report an enhanced sense of clarity and connection.
The Sananga Experience:
The application of Sananga is known for its brief yet intense sensation, lasting about 5–10 minutes. After the initial burning subsides, users often experience a sense of clarity, calm, and focus, feeling more connected and grounded.
The Path Forward:
As interest grows, Sananga continues to bridge Amazonian wisdom with modern spiritual practices, offering a unique tool for those seeking clarity and energetic balance.
Disclaimer: Sananga should be used under the guidance of an experienced practitioner and only where legally permitted. Approach with respect, intention, and awareness of local laws.
Rapé
Rapé: Sacred Amazonian Snuff for Grounding and Clarity
Rapé (pronounced ha-PAY) is a traditional Amazonian snuff made from tobacco and other medicinal herbs, used by indigenous tribes for spiritual and physical cleansing. Known for its grounding effects, rapé clears the mind, balances energy, and deepens meditation.
How Rapé Works:
Rapé is applied to the nostrils with a special pipe, creating an intense clearing effect. The tobacco and herbs stimulate the sinuses, promoting clarity, focus, and grounding.
Traditional Roots:
Used for centuries by Amazonian tribes like the Yawanawá and Huni Kuin, rapé is integral to spiritual rituals, helping cleanse energy, enhance focus, and connect to nature and spirit.
Potential Benefits:
Rapé offers both physical and spiritual benefits, including:
• Mental Clarity: Clears the mind, supporting focus and mindfulness.
• Energy Cleansing: Releases stagnant energies, restoring balance.
• Grounding: Promotes a sense of connection and centeredness.
The Rapé Experience:
The experience is brief but intense, bringing immediate clarity, grounding, and mental stillness. It’s often used in meditation and spiritual practices for centering and presence.
The Path Forward:
With growing interest, rapé is finding its place in modern wellness, bridging indigenous wisdom with mindfulness practices.
Disclaimer: Rapé should be used respectfully and only where legal, ideally with guidance from an experienced practitioner. Always approach with intention, respecting local customs and laws.
Rapé (pronounced ha-PAY) is a traditional Amazonian snuff made from tobacco and other medicinal herbs, used by indigenous tribes for spiritual and physical cleansing. Known for its grounding effects, rapé clears the mind, balances energy, and deepens meditation.
How Rapé Works:
Rapé is applied to the nostrils with a special pipe, creating an intense clearing effect. The tobacco and herbs stimulate the sinuses, promoting clarity, focus, and grounding.
Traditional Roots:
Used for centuries by Amazonian tribes like the Yawanawá and Huni Kuin, rapé is integral to spiritual rituals, helping cleanse energy, enhance focus, and connect to nature and spirit.
Potential Benefits:
Rapé offers both physical and spiritual benefits, including:
• Mental Clarity: Clears the mind, supporting focus and mindfulness.
• Energy Cleansing: Releases stagnant energies, restoring balance.
• Grounding: Promotes a sense of connection and centeredness.
The Rapé Experience:
The experience is brief but intense, bringing immediate clarity, grounding, and mental stillness. It’s often used in meditation and spiritual practices for centering and presence.
The Path Forward:
With growing interest, rapé is finding its place in modern wellness, bridging indigenous wisdom with mindfulness practices.
Disclaimer: Rapé should be used respectfully and only where legal, ideally with guidance from an experienced practitioner. Always approach with intention, respecting local customs and laws.
Yopo
Yopo: Ancestral Amazonian Snuff for Visionary Experiences
Yopo, a traditional snuff made from the seeds of the Anadenanthera tree, is used by indigenous Amazonian tribes for its powerful visionary effects. Known for deep spiritual experiences, Yopo is used in healing and ceremonial practices to connect with nature, spirit, and the self.
How Yopo Works:
Yopo seeds contain DMT and bufotenine, which, when inhaled, create intense visual and sensory effects. These compounds interact with serotonin receptors, inducing altered states of consciousness that open pathways to introspection.
Traditional Roots:
For centuries, tribes like the Yanomami and Piaroa have used Yopo in rituals to gain spiritual insight and connect with ancestors. Traditional Yopo ceremonies are led by experienced healers who provide guidance and support.
Potential Benefits:
Yopo is valued for its introspective and spiritual qualities, with potential benefits including:
• Spiritual Insight: Offers profound visions and transformative insights.
• Emotional Release: Helps individuals confront and process emotions.
• Connection with Nature: Enhances unity with the natural world.
The Yopo Experience:
The Yopo journey is intense, often lasting 30–60 minutes, with vivid visuals and altered perceptions. The experience is typically supported by a ceremonial setting for grounding and integration.
The Path Forward:
With renewed interest in indigenous practices, Yopo is being explored for its potential in modern spirituality and self-exploration, bridging ancestral wisdom with contemporary wellness.
Disclaimer: Yopo should be used respectfully and only where legal, ideally under the guidance of experienced practitioners. Approach responsibly, respecting local customs and laws.
Yopo, a traditional snuff made from the seeds of the Anadenanthera tree, is used by indigenous Amazonian tribes for its powerful visionary effects. Known for deep spiritual experiences, Yopo is used in healing and ceremonial practices to connect with nature, spirit, and the self.
How Yopo Works:
Yopo seeds contain DMT and bufotenine, which, when inhaled, create intense visual and sensory effects. These compounds interact with serotonin receptors, inducing altered states of consciousness that open pathways to introspection.
Traditional Roots:
For centuries, tribes like the Yanomami and Piaroa have used Yopo in rituals to gain spiritual insight and connect with ancestors. Traditional Yopo ceremonies are led by experienced healers who provide guidance and support.
Potential Benefits:
Yopo is valued for its introspective and spiritual qualities, with potential benefits including:
• Spiritual Insight: Offers profound visions and transformative insights.
• Emotional Release: Helps individuals confront and process emotions.
• Connection with Nature: Enhances unity with the natural world.
The Yopo Experience:
The Yopo journey is intense, often lasting 30–60 minutes, with vivid visuals and altered perceptions. The experience is typically supported by a ceremonial setting for grounding and integration.
The Path Forward:
With renewed interest in indigenous practices, Yopo is being explored for its potential in modern spirituality and self-exploration, bridging ancestral wisdom with contemporary wellness.
Disclaimer: Yopo should be used respectfully and only where legal, ideally under the guidance of experienced practitioners. Approach responsibly, respecting local customs and laws.
Kambo
Kambo: Amazonian Medicine for Cleansing and Resilience
Kambo, a traditional Amazonian medicine derived from the secretion of the Phyllomedusa bicolor (giant monkey frog), is used by indigenous tribes for its intense purifying effects. Known for supporting physical and emotional resilience, kambo is gaining interest for its potential benefits in holistic wellness.
How Kambo Works:
Kambo contains peptides that, when applied to small burns on the skin, enter the lymphatic system and create a powerful detoxifying response. This process can stimulate immune function, release toxins, and promote physical and mental clarity.
Traditional Roots:
Indigenous tribes in the Amazon, such as the Matsés and Katukina, use kambo in ceremonies to cleanse the body, increase stamina, and prepare for hunting. Kambo is applied with respect and intention, often accompanied by chanting and traditional rituals to guide the process.
Potential Benefits:
Kambo is valued for its purifying and resilience-building effects, with benefits that may include:
• Immune Support: Stimulates the immune system and supports physical health.
• Detoxification: Helps release toxins, promoting a sense of lightness and clarity.
• Emotional Release: Many report emotional relief and clarity after a session.
The Kambo Experience:
Kambo ceremonies are brief but intense, typically lasting 20–40 minutes. The initial effects include purging and sweating, followed by a period of recovery, where participants often feel lighter, clearer, and more grounded.
The Path Forward:
With growing interest, kambo is being explored as a tool for physical and emotional healing, bridging indigenous wisdom with modern wellness practices.
Disclaimer: Kambo should only be used with trained practitioners in safe, legal settings. Always approach responsibly, respecting cultural practices and local laws.
Kambo, a traditional Amazonian medicine derived from the secretion of the Phyllomedusa bicolor (giant monkey frog), is used by indigenous tribes for its intense purifying effects. Known for supporting physical and emotional resilience, kambo is gaining interest for its potential benefits in holistic wellness.
How Kambo Works:
Kambo contains peptides that, when applied to small burns on the skin, enter the lymphatic system and create a powerful detoxifying response. This process can stimulate immune function, release toxins, and promote physical and mental clarity.
Traditional Roots:
Indigenous tribes in the Amazon, such as the Matsés and Katukina, use kambo in ceremonies to cleanse the body, increase stamina, and prepare for hunting. Kambo is applied with respect and intention, often accompanied by chanting and traditional rituals to guide the process.
Potential Benefits:
Kambo is valued for its purifying and resilience-building effects, with benefits that may include:
• Immune Support: Stimulates the immune system and supports physical health.
• Detoxification: Helps release toxins, promoting a sense of lightness and clarity.
• Emotional Release: Many report emotional relief and clarity after a session.
The Kambo Experience:
Kambo ceremonies are brief but intense, typically lasting 20–40 minutes. The initial effects include purging and sweating, followed by a period of recovery, where participants often feel lighter, clearer, and more grounded.
The Path Forward:
With growing interest, kambo is being explored as a tool for physical and emotional healing, bridging indigenous wisdom with modern wellness practices.
Disclaimer: Kambo should only be used with trained practitioners in safe, legal settings. Always approach responsibly, respecting cultural practices and local laws.
Cacao
Cacao: Heart-Opening Medicine for Connection and Joy
Cacao, often used ceremonially in Central and South America, is cherished for its heart-opening effects and ability to foster connection and joy. Known as the “food of the gods,” ceremonial cacao is celebrated for its uplifting and grounding qualities, making it popular in wellness and spiritual practices.
How Cacao Works:
Cacao is rich in antioxidants, theobromine, and magnesium, which improve circulation, boost mood, and create a gentle, energized state. Its effects can help calm the mind, open the heart, and deepen connection with oneself and others.
Traditional Roots:
Indigenous cultures in Central and South America, particularly the Mayans and Aztecs, have used cacao in rituals for centuries to foster gratitude, connection, and celebration. Cacao ceremonies are filled with intention and reverence, bringing participants into a meditative and joyful state.
Potential Benefits:
Ceremonial cacao offers both physical and emotional benefits, including:
• Heart-Opening: Encourages emotional openness and connection.
• Mood Enhancement: Theobromine and serotonin precursors naturally boost mood.
• Mindful Presence: Supports focus and brings a calm, joyful awareness.
The Cacao Experience:
Cacao ceremonies are gentle and uplifting, often lasting 1–2 hours, where participants drink a warm cacao brew, meditate, and reflect. Many report feeling more open-hearted, connected, and present.
The Path Forward:
As interest grows, cacao ceremonies are becoming a popular way to cultivate mindfulness and connection, bridging ancient traditions with modern wellness practices.
Disclaimer: Cacao should be used mindfully and with respect for traditional practices. Always approach ceremonial cacao with intention and in a supportive, legal setting.
Cacao, often used ceremonially in Central and South America, is cherished for its heart-opening effects and ability to foster connection and joy. Known as the “food of the gods,” ceremonial cacao is celebrated for its uplifting and grounding qualities, making it popular in wellness and spiritual practices.
How Cacao Works:
Cacao is rich in antioxidants, theobromine, and magnesium, which improve circulation, boost mood, and create a gentle, energized state. Its effects can help calm the mind, open the heart, and deepen connection with oneself and others.
Traditional Roots:
Indigenous cultures in Central and South America, particularly the Mayans and Aztecs, have used cacao in rituals for centuries to foster gratitude, connection, and celebration. Cacao ceremonies are filled with intention and reverence, bringing participants into a meditative and joyful state.
Potential Benefits:
Ceremonial cacao offers both physical and emotional benefits, including:
• Heart-Opening: Encourages emotional openness and connection.
• Mood Enhancement: Theobromine and serotonin precursors naturally boost mood.
• Mindful Presence: Supports focus and brings a calm, joyful awareness.
The Cacao Experience:
Cacao ceremonies are gentle and uplifting, often lasting 1–2 hours, where participants drink a warm cacao brew, meditate, and reflect. Many report feeling more open-hearted, connected, and present.
The Path Forward:
As interest grows, cacao ceremonies are becoming a popular way to cultivate mindfulness and connection, bridging ancient traditions with modern wellness practices.
Disclaimer: Cacao should be used mindfully and with respect for traditional practices. Always approach ceremonial cacao with intention and in a supportive, legal setting.
Psychedelic Medicine
I THRIVE encourages caution and appropriate referrals to experienced, licensed, and trained medical doctors, psychiatrists, and psychedelic medicine clinicians prior to consideration of any psychedelic medicine healing or assisted treatment pursuits.
Information is provided here for educational purposes only.
This website makes no effort to support or advocate for any specific dogma, spiritual path, orientation, political or social agenda. We are not a source for legal advice.
The information shared on this website is for general information purposes only and is not intended to replace medical advice offered by healthcare professionals and physicians. If users have any personal questions regarding health, psychiatric, or psychological concerns, they are encouraged to contact a qualified health care provider for advice. All personal questions of the aforementioned nature posed to I THRIVE will be deferred.
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